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CBD Research For The Treatment Of Cancer

Leaf Vertical > Blog > CBD Research For The Treatment Of Cancer

In the United States, cannabinoids have been allowed for use in palliative medicine due to their effectiveness for pain-relief and effectiveness against vomiting and nausea, but increasing number of research studies have investigated and indicated their anticancer properties.

Research from the NCBI

The National Center for Biotechnology Information (NCBI) advances science and health by providing access to biomedical and genomic information. PubMed, one of many resources on NCBI’s website comprises more than 28 mission citations or biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher websites.

The following is a partial list of cancer research studies which have been published on the NCBI’s website.

General Cancer Research

Cannabidiol as potential anticancer drug
https://www.ncbi.nlm.nih.gov/pubmed/22506672

Cannabidiol inhibits angiogenesis by multiple mechanisms
https://www.ncbi.nlm.nih.gov/pubmed/22624859

The inhibitory effects of cannabidiol on systemic malignant tumors
https://www.ncbi.nlm.nih.gov/pubmed/23544909

Cannabidiol inhibits cancer cell invasion via up regulation of tissue inhibitor of matrix metalloproteinases-1
https://www.ncbi.nlm.nih.gov/pubmed/19914218

 

Lung Cancer Research

Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1C
https://www.ncbi.nlm.nih.gov/pubmed/22198381

COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells
https://www.ncbi.nlm.nih.gov/pubmed/23220503

Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells
https://www.ncbi.nlm.nih.gov/pubmed/20668920

 

Prostate / Colon Cancer Research

Towards the use of non-psychoactive cannabinoids for prostate cancer
https://www.ncbi.nlm.nih.gov/pubmed/22849856

Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent
https://www.ncbi.nlm.nih.gov/pubmed/22110202

Chemo preventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer
https://www.ncbi.nlm.nih.gov/pubmed/22231745

 

Breast Cancer Research

Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
https://www.ncbi.nlm.nih.gov/pubmed/16728591

Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross talk between apoptosis and autophagy
https://www.ncbi.nlm.nih.gov/pubmed/21566064

Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
https://www.ncbi.nlm.nih.gov/pubmed/20859676

Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
https://www.ncbi.nlm.nih.gov/pubmed/18025276

Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration
https://www.ncbi.nlm.nih.gov/pubmed/22963825

 

Glioblastoma / Brain Cancer Research

Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival
https://www.ncbi.nlm.nih.gov/pubmed/20053780

Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines(PubMed)
https://www.ncbi.nlm.nih.gov/pubmed/14617682

Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas
https://www.ncbi.nlm.nih.gov/pubmed/24142199

Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
https://www.ncbi.nlm.nih.gov/pubmed/15700028

Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target
https://www.ncbi.nlm.nih.gov/pubmed/23243024

Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents
https://www.ncbi.nlm.nih.gov/pubmed/23079154

Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect
https://www.ncbi.nlm.nih.gov/pubmed/24204703

Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme
https://www.ncbi.nlm.nih.gov/pubmed/23349970

 

Leukemia Cancer Research

Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression
https://www.ncbi.nlm.nih.gov/pubmed/16754784

Cannabidiol-Induced Apoptosis in Human Leukemia Cells
https://www.ncbi.nlm.nih.gov/pubmed/?term=Cannabidiol-Induced+Apoptosis+in+Human+Leukemia+Cells

 

Skin Cancer Research

Anticancer activity of anandamide in human cutaneous melanoma cells
https://www.ncbi.nlm.nih.gov/pubmed/24041928

 

Kaposi Sarcoma Cancer Research

Cannabidiol inhibits growth and induces programmed cell death in Kaposi Sarcoma-associated herpes virus-infected endothelium (PubMed)
https://www.ncbi.nlm.nih.gov/pubmed/23264851

 

Endocrine Cancer Research

Endocannabinoids in endocrine and related tumors
https://www.ncbi.nlm.nih.gov/pubmed/18508995

A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells
https://www.ncbi.nlm.nih.gov/pubmed/18387516

 

Bladder Cancer Research

TRPV2 activation induces apoptotic cell death in human T24 bladder cancer cells: a potential therapeutic target for bladder cancer
https://www.ncbi.nlm.nih.gov/pubmed/20546877

 

Pain in Cancer Patients Research

Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC: CBD extract and THC extract in patients with intractable cancer-related pain
https://www.ncbi.nlm.nih.gov/pubmed/19896326

Nabiximols for opioid-treated cancer patients with poorly controlled chronic pain: a randomized, placebo-controlled, graded-dose trial
https://www.ncbi.nlm.nih.gov/pubmed/22483680

 

About Leaf Vertical, Inc.

Leaf Vertical Inc. is an innovative, clinical-stage biopharmaceutical research company, committed to discovering and developing novel therapeutics from its proprietary cannabinoid product platform.

For more information on Leaf Vertical or its Cannabinoid (CBD) clinical trials, use in the treatment of specific types of malignancies related to glioblastoma, myeloma, gastrointestinal, and breast cancer, when administered in conjunction with Standard of Care, please contact Leaf Vertical by phone at 407-776-9217 or visit the company’s headquarters at 805 S. Kirkman Rd, Suite 202, Orlando, Florida 32811.

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